Understanding how brain receptors interact to regulate synaptic strength
Structure-guided functional analysis of GluA4-NPTX2 interaction during PVIN homeostatic scaling
This study is looking at how certain proteins in the brain work together to help with learning and memory, and it could lead to new treatments for conditions like schizophrenia, helping patients understand their condition better and find new ways to feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10930129 on NIH RePORTER |
What this research studies
This research investigates the interactions between AMPA-type glutamate receptors and the adhesion protein NPTX2, which are crucial for regulating synaptic strength in the brain. By using advanced imaging techniques like Cryo-electron microscopy, the study aims to reveal the structural details of these interactions and how they influence learning, memory, and psychiatric disorders. The findings could lead to new therapeutic strategies for conditions like schizophrenia by correcting imbalances in brain circuits. Patients may benefit from a better understanding of the underlying mechanisms of their conditions and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with psychiatric conditions such as schizophrenia that may be linked to synaptic dysfunction.
Not a fit: Patients with neurological disorders unrelated to synaptic strength or those without psychiatric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve treatment for psychiatric disorders by enhancing synaptic function.
How similar studies have performed: Other research has shown promising results in understanding receptor interactions and their implications for brain function, making this approach both innovative and grounded in prior success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Hale, William Dylan — Johns Hopkins University
- Study coordinator: Hale, William Dylan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.