Understanding how brain receptors affect memory and behavior
Characterization of Compartmentalized GPCR Signaling in Neurons
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11124093
This study is looking at how certain brain receptors affect memory and behavior, with the hope of finding new treatments for memory problems and mental health issues, using neurons made from human cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11124093 on ClinicalTrials.gov |
What this research studies
This research investigates the role of G protein-coupled receptors (GPCRs) in the brain, particularly focusing on how these receptors influence memory, behavior, and neuropsychiatric disorders. By examining the unique signaling pathways activated in different cellular compartments of neurons, the study aims to uncover the molecular mechanisms behind these processes. Using human-derived neurons, the research will explore how specific receptor activation leads to changes in gene expression and neuronal function, potentially paving the way for new therapies for memory disorders and mental illnesses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neuropsychiatric disorders or memory-related issues.
Not a fit: Patients with conditions unrelated to GPCR signaling or those not experiencing memory or behavioral issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more targeted and effective treatments for memory disorders and mental health conditions.
How similar studies have performed: Previous research has shown promising results in understanding GPCR signaling in other contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TSVETANOVA, NIKOLETA GEORGIEVA — DUKE UNIVERSITY
- Study coordinator: TSVETANOVA, NIKOLETA GEORGIEVA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.