Understanding how brain proteins affect memory formation
Official title: Activity-Dependent Regulation of CaMKII and Synaptic Plasticity
Funded at Brandeis University · NIH-11113840 · Data updated 2026-11-12
This study is looking at how a protein called CaMKII helps us form memories, and it's for anyone interested in understanding how our brains work and what might affect our ability to remember things.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $444,634 |
| NIH project number | 5R37NS112810-07 |
| Project ID | NIH-11113840 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who may be experiencing memory-related issues or are interested in the biological mechanisms of memory.
✕Less likely to help
Patients with no interest in memory research or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, CaMKII, in the formation of memories by examining how it is produced and localized in the brain. The study will explore whether certain sequences in the protein's genetic material are necessary for its function and how disruptions in this process might impact memory. By using advanced techniques like real-time assays and genome editing, researchers aim to uncover the mechanisms behind memory formation and the potential factors that influence it.
Why it matters
Potential benefit: If successful, this research could lead to new insights into memory-related disorders and potential therapeutic strategies for improving memory function.
How similar studies have gone: Previous research has shown promising results in understanding the role of CaMKII in memory, indicating that this approach has potential for significant findings.
Where this research is happening
-
Brandeis University
Waltham, United States Active
Researchers
- Principal investigator: Griffith, Leslie C — Brandeis University
- Study coordinator: Griffith, Leslie C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.