Understanding how brain processes affect sentence production in people with aphasia after a stroke

Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia

NIH-funded research Univ of Maryland, College Park · NIH-10885166

This study is looking at how brain processes affect the ability to form sentences in people who have trouble speaking after a stroke, with the goal of finding better ways to help them communicate.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniv of Maryland, College Park NIH-funded
Lab location1 site (College Park, United States)
Project IDNIH-10885166 on NIH RePORTER

What this research studies

This research investigates the complex mechanisms behind sentence production impairments in individuals with post-stroke agrammatic aphasia (PSA-G). It aims to improve communication interventions by exploring how various cognitive and motor processes interact during sentence formation and how these processes are disrupted in PSA-G. The study will utilize advanced methodologies to analyze the neural dynamics involved in language production, focusing on the timing and coordination of brain activity. By identifying the specific neural alterations that contribute to communication difficulties, the research seeks to inform more effective therapeutic strategies for patients.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who have experienced a stroke and are diagnosed with post-stroke agrammatic aphasia.

Not a fit: Patients who do not have aphasia or have other forms of communication disorders unrelated to agrammatic aphasia may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved communication therapies for individuals suffering from aphasia, enhancing their ability to express themselves.

How similar studies have performed: While some research has explored aspects of aphasia treatment, this study's specific focus on the neural mechanisms of sentence production in PSA-G represents a novel approach.

Where this research is happening

College Park, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.