Understanding how brain populations determine value in decision-making
CRCNS: Inferring reference points from OFC population dynamics
This study looks at how groups of brain cells help us make decisions by using reference points, and it aims to understand this better by observing rats, which could help us learn more about how our brains work when we weigh our choices and expectations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10887550 on NIH RePORTER |
What this research studies
This research investigates how groups of neurons in the brain represent reference points that influence decision-making in both humans and animal models. By studying rats, the researchers aim to develop a new behavioral paradigm that allows for the monitoring of large-scale neural activity during value-based decisions. The approach combines experimental techniques with theoretical modeling to analyze how expectations shape perceptions of gains and losses. This work could provide insights into the neural mechanisms underlying various cognitive processes related to decision-making.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with mood disorders, particularly those experiencing difficulties in decision-making related to gains and losses.
Not a fit: Patients who do not have mood disorders or cognitive impairments may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of decision-making processes, potentially leading to improved treatments for conditions like bipolar disorder and other affective disorders.
How similar studies have performed: Other research has shown success in using animal models to study decision-making processes, indicating that this approach is promising and builds on established methodologies.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Constantinople, Christine M — New York University
- Study coordinator: Constantinople, Christine M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.