Understanding how brain pathways affect timing in behavior
Official title: Roles of Descending Forebrain Pathways to the Cerebellum in Behavioral Timing
Funded at University of Iowa · NIH-11052527 · Data updated 2026-11-12
This study looks at how different parts of the brain talk to each other and how that affects timing in thinking for people with schizophrenia and bipolar disorder, hoping to find ways to help improve their cognitive skills.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $159,206 |
| NIH project number | 5R21MH136675-02 |
| Project ID | NIH-11052527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with schizophrenia or bipolar disorder who experience cognitive deficits.
✕Less likely to help
Patients without cognitive deficits or those not diagnosed with schizophrenia or bipolar disorder may not benefit from this research.
What this research studies
This research investigates how communication between the cerebellum and forebrain influences cognitive timing, particularly in individuals with schizophrenia and bipolar disorder. By focusing on the descending pathways from the medial frontal cortex to the cerebellum, the study aims to uncover the neural mechanisms that contribute to cognitive deficits associated with these conditions. Patients may benefit from insights into how their cognitive timing is affected, which could lead to targeted interventions. The research employs advanced neurobiological techniques to explore these pathways and their effects on behavior.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive deficits in patients with schizophrenia and bipolar disorder.
How similar studies have gone: Previous research has shown promising results in understanding cerebellar function in cognitive processes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Freeman, John H — University of Iowa
- Study coordinator: Freeman, John H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.