Understanding how brain pathways affect movement in Parkinson's disease
Official title: Characterizing the pathophysiological role of the pallido-thalamocortical motor pathway in Parkinson's disease
Funded at University of Minnesota · NIH-11004633 · Data updated 2026-11-12
This study is looking at how certain brain pathways affect movement problems in people with Parkinson's disease, especially focusing on how these pathways work together during movement, to help improve treatments like deep brain stimulation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $554,159 |
| NIH project number | 5R01NS128029-02 |
| Project ID | NIH-11004633 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience motor symptoms such as bradykinesia.
✕Less likely to help
Patients with Parkinson's disease who do not exhibit significant motor symptoms may not benefit from this research.
What this research studies
This research investigates the role of specific brain pathways in the development of motor symptoms in Parkinson's disease, particularly focusing on the basal ganglia thalamocortical circuit. By examining the synchronization of neural activity in these pathways, the study aims to uncover how these changes relate to the severity of symptoms like bradykinesia. The research will utilize advanced techniques to analyze brain activity and its modulation during movement, potentially leading to improved deep brain stimulation strategies. Patients may be involved in assessments that help clarify the relationship between brain activity and motor function.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for managing motor symptoms in Parkinson's disease.
How similar studies have gone: Previous research has shown promising results in understanding brain pathways in Parkinson's disease, but this specific approach is novel and aims to provide deeper insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Aman, Joshua E — University of Minnesota
- Study coordinator: Aman, Joshua E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.