Understanding how brain pacemakers regulate daily rhythms
Neural circuitry and functional significance of extra-SCN pacemakers
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10874405
This study is looking at how certain brain cells help control our body’s daily rhythms, like sleep and eating, especially when our routines are messed up by things like shift work or too much artificial light, to help us understand how these changes can affect our health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10874405 on ClinicalTrials.gov |
What this research studies
This research investigates the role of extra-suprachiasmatic nucleus (SCN) pacemakers in regulating circadian rhythms, which are essential for daily behavior and physiological functions. By utilizing advanced molecular and imaging techniques, the study aims to identify the neural circuitry and physiological outputs associated with these pacemakers. The findings could reveal how these extra-SCN pacemakers interact with the SCN to influence sleep and feeding behaviors, particularly in the context of disruptions caused by shift work or artificial light exposure. This research is crucial for understanding the underlying mechanisms of circadian dysregulation and its impact on health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing sleep disorders, circadian rhythm disruptions, or those affected by neurological disorders and substance use.
Not a fit: Patients with stable circadian rhythms and no sleep-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sleep disorders and conditions related to circadian rhythm disruptions.
How similar studies have performed: Previous research has shown promising results in understanding circadian rhythms, but the specific focus on extra-SCN pacemakers is a novel approach.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAMAZAKI, SHIN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: YAMAZAKI, SHIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.