Understanding how brain neurons connect and communicate
Long-range neuronal projections: circuit blueprint or stochastic targeting? Rigorous classification of brain-wide axonal reconstructions
['FUNDING_OTHER'] · GEORGE MASON UNIVERSITY · NIH-10360723
This study is exploring how brain cells connect and communicate with each other to help us understand how our brains work, which could lead to better treatments for brain-related health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGE MASON UNIVERSITY (nih funded) |
| Locations | 1 site (FAIRFAX, UNITED STATES) |
| Trial ID | NIH-10360723 on ClinicalTrials.gov |
What this research studies
This research investigates the long-range connections between neurons in the brain to understand how they communicate and form networks. By utilizing advanced microscopic imaging and genetic labeling techniques, the project aims to classify different types of projection neurons based on their anatomical targeting patterns. The research employs a data-driven approach to analyze large-scale brain reconstructions, testing whether neuron connections follow specific patterns or occur randomly. This work is part of the BRAIN initiative, which seeks to advance our understanding of brain function and its implications for health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that affect brain connectivity or function.
Not a fit: Patients with purely psychological conditions without a neurological basis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain connectivity that may improve treatments for neurological disorders.
How similar studies have performed: Previous research in brain connectivity and neuron classification has shown promising results, indicating that this approach could yield significant insights.
Where this research is happening
FAIRFAX, UNITED STATES
- GEORGE MASON UNIVERSITY — FAIRFAX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ASCOLI, GIORGIO A — GEORGE MASON UNIVERSITY
- Study coordinator: ASCOLI, GIORGIO A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.