Understanding how brain networks influence Alzheimer's disease development
Official title: Network drivers of regional vulnerability to early Alzheimer's disease pathology
Funded at University of California Berkeley · NIH-10903030 · Data updated 2026-11-12
This study is looking at how two proteins related to Alzheimer's disease behave in the brain and how they might affect brain connections, especially in older adults, to help us understand the early signs of the disease and how it progresses.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $45,965 |
| NIH project number | 1F31AG087648-01 |
| Project ID | NIH-10903030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who may be at risk for Alzheimer's disease, particularly those with early signs of cognitive decline.
✕Less likely to help
Patients who are not at risk for Alzheimer's disease or who do not exhibit any cognitive decline may not benefit from this research.
What this research studies
This research investigates the interactions between beta-amyloid and tau proteins in the brain, which are linked to Alzheimer's disease and cognitive decline. By utilizing advanced imaging techniques like positron emission tomography (PET) and resting-state fMRI, the study aims to explore how these proteins accumulate and spread in relation to brain network connectivity. The goal is to identify patterns that may indicate vulnerability to Alzheimer's pathology, particularly in older adults. This could help in understanding the early stages of Alzheimer's and how brain activity influences disease progression.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for early detection and intervention in Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between brain networks and Alzheimer's pathology, indicating that this approach has potential for significant insights.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Fonseca, Corrina — University of California Berkeley
- Study coordinator: Fonseca, Corrina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.