Understanding how brain networks function in attention and memory.
Circuit Mechanisms Governing the Default Mode Network
This study is looking at how a specific part of the brain, called the default mode network, works when awake, which could help us understand and improve treatments for conditions like Alzheimer's and ADHD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11030799 on NIH RePORTER |
What this research studies
This research investigates the default mode network (DMN) in the brain, which is important for various behaviors, including attention and memory. Using advanced imaging techniques in awake rodents, the study aims to uncover the cellular and circuit mechanisms that govern how the DMN operates. By employing a novel silent zero-echo-time fMRI method, researchers can observe how the DMN responds to different stimuli, which may help bridge the gap between animal and human studies. This could lead to better understanding and treatment of conditions like Alzheimer's disease and ADHD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, ADHD, or related cognitive disorders.
Not a fit: Patients with cognitive disorders unrelated to the default mode network may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with cognitive disorders.
How similar studies have performed: Other research has shown promise in understanding brain networks using advanced imaging techniques, suggesting potential for success in this approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Shih, Yen-Yu Ian — Univ of North Carolina Chapel Hill
- Study coordinator: Shih, Yen-Yu Ian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.