Understanding how brain networks control sleep and wakefulness in humans
Official title: Ascending Arousal Network Control of Sleep-Wake Structure in Humans Using Simultaneous EEG and High-Resolution fMRI
Funded at Boston University Medical Campus · NIH-10996254 · Data updated 2026-11-12
This study is looking at how different parts of the brain work together to help us switch between sleeping and waking, and it's for anyone interested in understanding more about sleep and sleep disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31NS139696-01 |
| Project ID | NIH-10996254 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing sleep disturbances or cognitive decline, particularly those at risk for or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients without sleep issues or those not affected by cognitive decline may not benefit from this research.
What this research studies
This research investigates the brain's ascending arousal network (AAN) and its role in regulating sleep-wake cycles in humans. By using advanced imaging techniques, including simultaneous EEG and high-resolution fMRI, the study aims to observe how different brain regions communicate and coordinate to manage transitions between sleep and wakefulness. Participants will undergo a four-hour MRI scan while sleeping, allowing researchers to gather detailed data on brain activity and its impact on sleep structure. The findings could enhance our understanding of sleep disorders and cognitive functions related to sleep.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sleep disorders and better management of cognitive decline associated with conditions like Alzheimer's disease.
How similar studies have gone: Previous research in animal models has shown success in understanding the AAN's role in sleep regulation, but this study aims to explore these mechanisms in humans, making it a novel approach.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Cicero, Nicholas Gregory — Boston University Medical Campus
- Study coordinator: Cicero, Nicholas Gregory
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.