Understanding how brain MRI and genes affect thinking skills in adults with congenital heart disease.
Exploring the relationship between advanced multimodal brain MRI phenotypes, genes and cognitive outcome in adults with CHD
This study is looking at how brain scans and genetics might affect thinking skills in adults with a specific heart condition called dextro-transposition of the great arteries (d-TGA), so we can better understand who might need extra help in their daily lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11015847 on NIH RePORTER |
What this research studies
This research investigates the link between advanced brain MRI imaging, genetic factors, and cognitive outcomes in adults who have congenital heart disease (CHD). It focuses on individuals with dextro-transposition of the great arteries (d-TGA), a common and severe form of CHD. By analyzing brain images and genetic information, the study aims to identify predictors of neuropsychological deficits, particularly in executive functions, which are crucial for daily living. The goal is to improve the allocation of interventions and support for those who may need it most.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have been diagnosed with congenital heart disease, particularly those with dextro-transposition of the great arteries.
Not a fit: Patients without congenital heart disease or those who do not have cognitive impairments related to their condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification of adults with CHD who are at risk for cognitive impairments, allowing for targeted interventions to improve their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding cognitive outcomes in patients with congenital heart disease, making this approach both relevant and potentially impactful.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Grant, Patricia Ellen — Boston Children's Hospital
- Study coordinator: Grant, Patricia Ellen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.