Understanding how brain molecules affect memory across different ages
Uncovering brain-wide molecular determinants of individual memory performance across lifespan
This study is looking at how our brains form long-term memories and how this process changes as we get older, using a tiny worm to help us understand the important molecules involved, which could give us clues about memory and aging, including conditions like Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10472237 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that contribute to long-term memory formation and how these mechanisms vary among individuals, particularly as they age. By using the simple organism C. elegans, which has a fully mapped nervous system, the researchers aim to identify the specific molecules involved in memory processes. The study combines behavioral training with advanced techniques to capture detailed molecular changes in the nervous system that are essential for memory. Insights gained from this research could enhance our understanding of normal brain function and age-related cognitive decline, including Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related memory issues or those at risk for Alzheimer's disease.
Not a fit: Patients with acute memory loss due to non-age-related factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving memory and addressing cognitive decline in aging populations.
How similar studies have performed: Previous research using similar molecular approaches in simpler organisms has shown promising results, suggesting potential for success in this study.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Arey, Rachel Nicole — Baylor College of Medicine
- Study coordinator: Arey, Rachel Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.