Understanding how brain mechanisms affect walking in Parkinson's disease
Neurophysiology of impaired gait in mouse models of Parkinson’s disease
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11044333
This study is looking at how certain parts of the brain help control walking, especially in mice with Parkinson's disease, to find new ways to improve walking difficulties for people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11044333 on ClinicalTrials.gov |
What this research studies
This research investigates the neural mechanisms that control walking, particularly in mouse models of Parkinson's disease. By focusing on the basal ganglia, which are crucial for movement, the study aims to understand how these brain regions influence gait at a detailed level. Researchers will employ advanced techniques such as high-speed video, automated tracking, and electrophysiology to analyze how specific brain cells contribute to walking patterns. The goal is to identify potential targets for improving therapies for gait impairment in Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience gait impairments.
Not a fit: Patients without Parkinson's disease or those who do not have gait issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for improving walking abilities in patients with Parkinson's disease.
How similar studies have performed: Previous research has shown promise in understanding movement disorders through similar neurophysiological approaches, indicating potential for success in this area.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MASMANIDIS, SOTIRIS — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: MASMANIDIS, SOTIRIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Animal Disease Models