Understanding how brain mechanisms affect bladder pain and control
Neural Mechanisms Underlying IC/BPS
This study is looking at how certain brain cells affect bladder pain and control in people with interstitial cystitis/bladder pain syndrome, and it hopes to find new ways to help relieve their symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11039833 on NIH RePORTER |
What this research studies
This research investigates the neural mechanisms involved in interstitial cystitis/bladder pain syndromes (IC/BPS), a condition characterized by severe bladder pain and loss of bladder control. The study focuses on specific brainstem neurons that influence pain processing and bladder function. Using advanced techniques like optogenetics and in vivo calcium imaging, researchers aim to uncover how these neurons change in response to IC/BPS and whether reversing these changes can alleviate symptoms. The findings could lead to new therapeutic approaches for managing this debilitating condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with interstitial cystitis or bladder pain syndrome experiencing significant bladder pain and dysfunction.
Not a fit: Patients without a diagnosis of interstitial cystitis or bladder pain syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer and more effective treatments for patients suffering from bladder pain syndromes.
How similar studies have performed: Previous research has shown promise in understanding neural mechanisms related to pain and bladder function, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Samineni, Vijay K — Washington University
- Study coordinator: Samineni, Vijay K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.