Understanding how brain inputs affect memory in Alzheimer's disease
Official title: Dynamics of Hippocampal Inputs in Alzheimer's Disease
Funded at Stanford University · NIH-10931456 · Data updated 2026-11-12
This study is looking at how certain brain cells in the hippocampus help with memory and what happens to memory when these cells are lost in Alzheimer's disease, using mice to learn more about how we might improve memory for people with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $122,931 |
| NIH project number | 5K99NS134734-02 |
| Project ID | NIH-10931456 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are experiencing memory issues related to Alzheimer's disease.
✕Less likely to help
Patients who are younger than 65 or do not have Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of specific brain cells in the hippocampus that are crucial for memory and how their loss in Alzheimer's disease affects memory function. By studying mice with Alzheimer's, the researchers will observe how these brain cells influence the processing of new and old memories during different memory tasks. The approach involves advanced techniques to record brain activity while the mice engage in tasks that test their spatial memory. This could lead to insights into potential treatments for memory impairment in Alzheimer's patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving memory function in individuals with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding brain function related to memory, making this approach a continuation of established findings.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Aery Jones, Emily Aster — Stanford University
- Study coordinator: Aery Jones, Emily Aster
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.