Understanding how brain injury affects immune responses
Novel mechanisms suppressing the pro-resolving phenotype of peripheral innate immunity following traumatic brain injury
This study is looking at how the body's immune system responds after a traumatic brain injury and how certain signals can help improve healing and reduce inflammation, which could lead to better treatments for patients recovering from such injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-11065508 on NIH RePORTER |
What this research studies
This research investigates the role of peripheral innate immunity in the aftermath of traumatic brain injury (TBI). It focuses on how certain signaling pathways, particularly EphA4/mTOR, influence the immune response and recovery process. By studying the behavior of immune cells derived from the blood, the research aims to uncover mechanisms that could lead to improved healing and reduced inflammation after brain trauma. Patients may benefit from insights that could inform new treatments targeting immune responses following TBI.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are experiencing ongoing symptoms or complications.
Not a fit: Patients with chronic neurological conditions unrelated to traumatic brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance recovery and reduce complications after traumatic brain injuries.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in brain injury, suggesting that this approach could yield valuable insights.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Theus, Michelle Lee — Virginia Polytechnic Inst and St Univ
- Study coordinator: Theus, Michelle Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.