Understanding how brain injuries progress and finding ways to improve recovery
Spreading Depolarizations and Neuronal Vulnerability
This study is looking at how certain brain injuries, like strokes, affect the brain and how a process called spreading depolarization can both hurt and help recovery, with the hope of finding new ways to improve healing and quality of life for patients after an injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project ID | NIH-11133388 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind acute brain injuries, such as strokes and trauma, focusing on a phenomenon called spreading depolarization (SD). By studying brain slices and animal models, the researchers aim to identify how SD can both harm and potentially help brain recovery. The ultimate goal is to develop interventions that can be applied even after the initial injury, improving survival rates and quality of life for patients. The research seeks to balance the detrimental and beneficial effects of SD to enhance recovery strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced acute brain injuries, such as strokes or traumatic brain injuries.
Not a fit: Patients with chronic brain conditions or those who have not recently experienced an acute brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and survival for patients with acute brain injuries.
How similar studies have performed: Previous research has shown promise in understanding the effects of spreading depolarization, but this specific approach is still being explored and is considered novel.
Where this research is happening
Albuquerque, United States
- University of New Mexico Health Scis Ctr — Albuquerque, United States (Active)
Researchers
- Principal investigator: Shuttleworth, Claude W — University of New Mexico Health Scis Ctr
- Study coordinator: Shuttleworth, Claude W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.