Understanding how brain injuries lead to long-term nerve damage
Mechanisms of Chronic Progressive Axon Degeneration Following TBI
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10874551
This study is looking at how moderate to severe traumatic brain injuries can affect nerve cells over time, especially how they can lead to ongoing damage that impacts communication in the brain, with the goal of finding ways to help people with TBI maintain their thinking skills.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10874551 on ClinicalTrials.gov |
What this research studies
This research investigates the long-term effects of moderate to severe traumatic brain injury (TBI) on nerve cells, focusing on how these injuries can cause ongoing degeneration of axons, which are crucial for communication between brain cells. The study aims to uncover the mechanisms behind this degeneration, particularly how the initial injury influences the progression of nerve damage over time. By examining both the acute and chronic phases of TBI, researchers hope to identify potential targets for intervention that could mitigate cognitive decline in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced moderate to severe traumatic brain injuries and are experiencing cognitive decline.
Not a fit: Patients with mild TBIs or those without any history of brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or slow down cognitive decline in patients who have suffered from traumatic brain injuries.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of nerve degeneration following brain injuries, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOHNSON, VICTORIA ELEANOR — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: JOHNSON, VICTORIA ELEANOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease