Understanding how brain injuries in preterm infants affect development
Overcoming the Inhibitory Neurovascular Niche in Preterm Infant Brain Injury
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11070396
This study is looking at how bleeding in the brain affects the brain development of preterm babies, and it aims to find ways to help prevent problems with their growth and learning by understanding a protein called fibrinogen.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11070396 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of central nervous system hemorrhage on the brain development of preterm infants. It focuses on understanding the molecular signals that disrupt cerebellar maturation due to bleeding in the brain. By studying the role of fibrinogen, a protein involved in blood clotting, the research aims to identify potential therapeutic targets to prevent neurodevelopmental impairments. The approach includes using animal models to explore how fibrinogen affects neuroinflammation and brain repair processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are preterm infants who are at risk for central nervous system hemorrhage.
Not a fit: Patients who are not preterm or do not have a history of brain hemorrhage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent developmental disabilities in preterm infants who experience brain hemorrhage.
How similar studies have performed: Other research has shown promising results in understanding the role of neuroinflammation in brain injuries, suggesting that this approach may yield significant insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PETERSEN, MARK A — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: PETERSEN, MARK A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease