Understanding how brain injuries affect men and women differently to improve treatment with nanoparticles
Exploiting sex-dependent brain injury response for nanoparticle therapeutics
This study is looking at how brain injuries affect men and women differently to improve treatments using tiny drug-carrying particles, helping doctors create better care options based on whether a patient is male or female.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10990513 on NIH RePORTER |
What this research studies
This research investigates how traumatic brain injuries (TBI) impact males and females differently, particularly focusing on how these differences affect the delivery of nanoparticle-based therapies. By studying the mechanisms behind blood-brain barrier (BBB) disruption in both sexes, the researchers aim to enhance the effectiveness of drug delivery systems designed to treat TBI. The approach involves using animal models to explore the role of sex hormones in influencing the BBB's response to injury and the subsequent delivery of therapeutic nanoparticles. This could lead to more tailored and effective treatments for brain injuries based on a patient's sex.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury, with a focus on understanding differences in treatment responses between males and females.
Not a fit: Patients who have not suffered a traumatic brain injury or those with pre-existing conditions that significantly alter their response to treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for treating traumatic brain injuries, potentially enhancing recovery outcomes for patients.
How similar studies have performed: While the use of nanoparticles for drug delivery is a growing field, this specific focus on sex-dependent responses in TBI is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Stabenfeldt, Sarah E — Arizona State University-Tempe Campus
- Study coordinator: Stabenfeldt, Sarah E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.