Understanding how brain injuries affect immune and metabolic responses
Official title: Immunometabolic regulation after CNS injury
Funded at Augusta University · NIH-10737334 · Data updated 2026-11-12
This study is looking at how a traumatic brain injury can affect the brain's immune and energy systems, which might lead to memory problems later on, and it aims to find out how certain brain cells can help us understand and possibly prevent these issues for people who have had brain injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | September 21, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,975,262 |
| NIH project number | 1RF1NS131731-01A1 |
| Project ID | NIH-10737334 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced a traumatic brain injury and are at risk for cognitive impairment or dementia.
✕Less likely to help
Patients who have not experienced a traumatic brain injury or those with pre-existing neurodegenerative conditions unrelated to TBI may not benefit from this research.
What this research studies
This research investigates the effects of traumatic brain injury (TBI) on the brain's immune and metabolic systems, which may lead to long-term cognitive issues like dementia. The study aims to understand how changes in brain metabolism can trigger inflammatory responses that contribute to neurodegeneration after TBI. By focusing on specific brain cells called astrocytes and their role in inflammation, the research seeks to uncover mechanisms that could help prevent cognitive decline in individuals with a history of brain injuries.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cognitive decline and dementia in patients who have suffered traumatic brain injuries.
How similar studies have gone: Previous research has shown promising results in understanding the link between brain injuries and cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Dhandapani, Krishnan M. — Augusta University
- Study coordinator: Dhandapani, Krishnan M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.