Understanding how brain immune cells respond to injury and disease
Official title: Statistical Methods for Confocal Microscopy Images of Microglia
Funded at University of Rochester · NIH-11055975 · Data updated 2026-11-12
This study is looking at special brain cells called microglia that help protect the brain when it's hurt or sick, and it's for anyone interested in understanding how these cells change shape and function, which could lead to better ways to understand brain health and diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $346,500 |
| NIH project number | 5R01NS136626-02 |
| Project ID | NIH-11055975 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurodegenerative diseases, brain injuries, or those affected by environmental toxins.
✕Less likely to help
Patients with conditions unrelated to brain health or those who do not have any neurological issues may not benefit from this research.
What this research studies
This research focuses on microglia, the immune cells in the brain that respond to injury and disease. By using advanced confocal microscopy techniques, the project aims to analyze the changes in microglial morphology and how these changes relate to their immune functions. The goal is to develop better methods for processing and analyzing images of microglia, which could help link their physical changes to their roles in brain health and disease. This could provide insights into neurodevelopment, neurodegenerative diseases, and the impact of environmental factors on brain function.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for various brain conditions and injuries.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to study microglial functions, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Mccall, Matthew Nicholson — University of Rochester
- Study coordinator: Mccall, Matthew Nicholson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.