Understanding how brain immune cells multiply
Mechanism of microglia proliferation
This study is looking at how certain brain cells called microglia grow and work, especially in conditions like Alzheimer's and after brain injuries, to help us understand how they affect brain health and could lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11099884 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the proliferation of microglia, which are immune cells in the brain, particularly in the context of various neurological disorders like Alzheimer's disease and traumatic brain injuries. By utilizing advanced techniques such as single-cell imaging and RNA sequencing, the study aims to uncover the genetic factors that regulate microglial growth and their role in neurological health. Patients may benefit from insights gained into how microglia contribute to disease progression and recovery, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing neurological conditions such as Alzheimer's disease or have suffered from brain injuries.
Not a fit: Patients with neurological disorders unrelated to microglial function or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target microglial proliferation, improving outcomes for patients with neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding microglial behavior in other neurological contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Guan, Zhonghui — University of California, San Francisco
- Study coordinator: Guan, Zhonghui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.