Understanding how brain immune cells affect small vessel disease and cognitive impairment
Role of Microglia in Cerebral Small Vessel Disease (CSVD)/Vascular Cognitive Impairment (VCI)
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10862730
This study is looking at how certain brain cells called microglia affect brain health in people with small vessel disease and memory problems, using a special rodent model to see how genetics and diet play a role, and it aims to find out what happens when these cells are reduced.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10862730 on ClinicalTrials.gov |
What this research studies
This research investigates the role of microglia, the brain's immune cells, in cerebral small vessel disease (CSVD) and vascular cognitive impairment (VCI), which are significant causes of dementia. The study uses a novel rodent model to explore how specific genetic and dietary factors influence microglial behavior and brain health. Researchers will analyze gene expression in these cells and assess the impact of a treatment that depletes microglia on neurological outcomes. Advanced imaging techniques will be employed to monitor changes in brain structure and function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive impairment related to vascular issues, particularly older adults with risk factors for small vessel disease.
Not a fit: Patients with cognitive impairment not related to vascular issues or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating cognitive decline associated with small vessel disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in brain diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEINSTEIN, JONATHAN R — UNIVERSITY OF WASHINGTON
- Study coordinator: WEINSTEIN, JONATHAN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.