Understanding how brain immune cells affect glioblastoma growth
Deciphering the role of Microglia in Glioblastoma
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10911325
This study is looking at how the brain's immune cells, called microglia, behave in glioblastoma, a tough type of brain tumor, to find new ways to help improve treatment for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10911325 on ClinicalTrials.gov |
What this research studies
This research investigates the role of microglia, the brain's immune cells, in glioblastoma, a highly aggressive brain tumor. The study aims to uncover how these cells, despite being abundant in tumors, fail to control tumor growth and may even aid in its progression. By isolating and analyzing the genetic activity of microglia within glioblastomas, researchers hope to identify new therapeutic targets that could improve treatment outcomes for patients. The approach involves advanced techniques like RNA sequencing to understand the changes in microglial behavior in the tumor environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking new treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that enhance the immune response against glioblastoma, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in targeting immune cells in cancer treatment, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EL-KHOURY, JOSEPH EL — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: EL-KHOURY, JOSEPH EL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.