Understanding how brain immune cells affect dopamine systems during adolescence
Epigenetic Regulation of Microglia Dopamine System Interactions
['FUNDING_FELLOWSHIP'] · DUKE UNIVERSITY · NIH-11023074
This study looks at how special immune cells in the brain, called microglia, help shape the dopamine system during teenage years, which is important for understanding why some young people might take risks or develop addiction problems.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11023074 on ClinicalTrials.gov |
What this research studies
This research investigates the role of microglia, the brain's immune cells, in the development of the dopamine system during adolescence. It focuses on how these cells prune synapses and receptors in the nucleus accumbens, a key brain region associated with reward and substance use. By studying rats, the research aims to uncover the mechanisms that regulate microglial behavior and its impact on dopamine receptor levels, which are crucial for understanding the onset of substance use disorders in adolescents. The findings could provide insights into how brain development influences risk-taking behaviors and addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12 to 20 who may be at risk for substance use disorders.
Not a fit: Patients who are not in the adolescent age range or do not have a history of substance use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for substance use disorders in adolescents.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CLARK, MADELINE J — DUKE UNIVERSITY
- Study coordinator: CLARK, MADELINE J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.