Understanding how brain function affects compulsive behaviors
Experimental Manipulation of OFC Function and Behavioral Context: Towards an Integrative Translational Model of Compulsive Behaviors
This study is looking at how certain brain areas affect compulsive behaviors, like those seen in obsessive-compulsive disorder, using animal models to help find better treatments for people who struggle with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10906751 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind compulsive behaviors, which are repetitive actions often aimed at reducing distress. By using animal models, the study explores how specific brain circuits, particularly the orbitofrontal cortex, influence these behaviors. The researchers employ advanced techniques to manipulate brain activity and observe the resulting changes in behavior, aiming to uncover the causal relationships that contribute to compulsive actions. This work seeks to bridge the gap between animal studies and human conditions, providing insights that could lead to better treatments for those affected by obsessive-compulsive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing obsessive-compulsive behaviors or related psychological conditions.
Not a fit: Patients with compulsive behaviors that are not linked to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for individuals suffering from compulsive behaviors and related disorders.
How similar studies have performed: Previous studies using animal models have shown promising results in understanding the brain mechanisms behind compulsive behaviors, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Price, Rebecca — University of Pittsburgh at Pittsburgh
- Study coordinator: Price, Rebecca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.