Understanding how brain fluid production affects aging and Alzheimer's disease
Official title: Investigating the role of CSF production and circulation in aging and Alzheimer's disease
Funded at University of Cincinnati · NIH-11087520 · Data updated 2026-11-12
This study is looking at how a part of the brain called the choroid plexus and the fluid around it help keep our brains healthy as we get older and deal with Alzheimer's disease, and it's for anyone interested in understanding how to better support brain health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $589,367 |
| NIH project number | 5R01AG083164-03 |
| Project ID | NIH-11087520 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing cognitive decline or are at risk for Alzheimer's disease.
✕Less likely to help
Patients with cognitive impairments not related to aging or Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of the choroid plexus and cerebrospinal fluid (CSF) in maintaining brain health, particularly as it relates to aging and Alzheimer's disease. The study aims to catalog molecules involved in CSF production and circulation, and how these molecules influence brain development and immune interactions. By using a novel mouse model, researchers will explore the effects of CSF on cognitive decline and the clearance of harmful proteins associated with Alzheimer's. This work could lead to new insights into how to support brain function as we age.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive health and slow the progression of Alzheimer's disease.
How similar studies have gone: Previous studies have shown promising results in animal models regarding the role of CSF in cognitive health, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Luo, Yu — University of Cincinnati
- Study coordinator: Luo, Yu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.