Understanding how brain fluid levels affect brain function
A Chemosensory-Mechanotransduction System Regulating Ventricular Size and Brain Function
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11063297
This study is looking at how the brain controls the size of its fluid-filled spaces in people with certain types of hydrocephalus, which can affect brain function, to find new ways to help improve their symptoms.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11063297 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which the brain regulates the size of its ventricles and how this impacts overall brain function. It focuses on patients with idiopathic normal pressure hydrocephalus (iNPH) and low pressure hydrocephalus, conditions where ventricular size increases without typical causes. The study explores a chemosensory-mechanotransduction system involving ependymal cells and motile cilia that may influence cerebrospinal fluid (CSF) dynamics and neuronal activity. By examining these processes, the research aims to uncover potential therapeutic targets for improving symptoms associated with these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with idiopathic normal pressure hydrocephalus or low pressure hydrocephalus.
Not a fit: Patients with obstructive hydrocephalus or those without any cerebrospinal fluid dynamics issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate symptoms of iNPH and improve brain function in affected patients.
How similar studies have performed: While some studies have explored related mechanisms, this specific approach focusing on ependymal chemosensory systems is relatively novel and untested.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOHNSON, MARK D — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: JOHNSON, MARK D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.