Understanding how brain factors influence decision-making and addiction.
Neurotrophic and ontogenic factors in medial orbitofrontal cortical function
This study is looking at how a part of the brain helps people make choices based on what they hope to gain, especially for those struggling with addiction, and it aims to find ways to improve decision-making for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10908344 on NIH RePORTER |
What this research studies
This research investigates how the medial orbitofrontal cortex (MO) in the brain helps individuals make decisions based on anticipated rewards, especially in the context of addiction. It focuses on the role of a neurotrophic factor called Brain-Derived Neurotrophic Factor (BDNF) and its receptor in maintaining the function of the MO. By studying how these factors affect decision-making processes, the research aims to uncover the underlying mechanisms that lead to maladaptive behaviors in individuals with substance use disorders. The findings could help identify new therapeutic targets for improving decision-making in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include adolescents and adults who are experiencing substance use disorders.
Not a fit: Patients who do not have issues with substance use or decision-making may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance decision-making abilities in individuals struggling with addiction.
How similar studies have performed: Previous research has shown promising results in understanding the role of neurotrophic factors in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Gourley, Shannon Leigh — Emory University
- Study coordinator: Gourley, Shannon Leigh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.