Understanding how brain connectivity changes after a stroke
Official title: Shift from Unilateral to Bilateral Sensory-Motor Connectivity in Chronic Hemiparetic Stroke
Funded at University of Illinois at Urbana-Champaign · NIH-10918117 · Data updated 2026-11-12
This study is looking at how the brain changes after a stroke, especially for people who have trouble moving their arms and hands, to help find better ways to support recovery and improve movement.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project start | December 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $331,501 |
| NIH project number | 5R01HD109157-04 |
| Project ID | NIH-10918117 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a hemiparetic stroke and exhibit abnormal movement patterns in their affected limbs.
✕Less likely to help
Patients who have not had a stroke or those with other neurological conditions unrelated to hemiparesis may not benefit from this research.
What this research studies
This research investigates how the brain's sensory and motor pathways adapt following a stroke, particularly focusing on patients who experience abnormal movement patterns. It aims to understand the shift in sensory information processing from the affected side of the body to the unaffected side, which may contribute to difficulties in arm and hand function. By using advanced imaging techniques, the study will explore the relationship between these changes in brain connectivity and the motor impairments that arise after a stroke. The findings could provide insights into new rehabilitation strategies for stroke survivors.
Why it matters
Potential benefit: If successful, this research could lead to improved rehabilitation techniques that enhance recovery of arm and hand function in stroke patients.
How similar studies have gone: Previous research has shown promising results in understanding brain connectivity changes after stroke, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Illinois at Urbana-Champaign
Champaign, United States Active
Researchers
- Principal investigator: Yang, Yuan — University of Illinois at Urbana-Champaign
- Study coordinator: Yang, Yuan
Related research
Other NIH-funded projects on the same topics.
-
Stroke prevention with hydroxyurea for children with sickle cell anemia in Nigeria
A multinational, patient-facing study tests whether hydroxyurea can safely prevent first strokes in Nigerian children with sickle cell anemia.
-
Music-powered tools to boost blood pressure and stroke prevention for Nigerian youth and their older caregivers
This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
-
Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
-
LRP1 controls NSC movement and stroke recovery
This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
-
BBB Dysfunction after Stroke and Risk for Dementia
A study at Stanford will look at whether inflammation after a stroke leads to leaky blood vessels and later dementia, by following stroke survivors and comparing them with people without stroke.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.