Understanding how brain connectivity affects attention and cognition in temporal lobe epilepsy
Relating Vigilance to Connectivity and Neurocognition in Temporal Lobe Epilepsy
This study is looking at how attention and brain connections affect thinking skills in people with temporal lobe epilepsy, to help understand why they sometimes have trouble with things like focus and decision-making, even if those issues aren't directly related to their seizures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10618398 on NIH RePORTER |
What this research studies
This research investigates the relationship between vigilance, brain connectivity, and cognitive function in patients with temporal lobe epilepsy (TLE). It aims to understand why TLE patients experience cognitive deficits that are not directly linked to the temporal lobe, such as issues with attention and executive function. By using neuroimaging techniques, the study will explore how recurrent seizures may disrupt brain networks involved in vigilance, potentially leading to broader cognitive impairments. The research will involve assessing brain connectivity and cognitive performance in relation to vigilance levels.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with temporal lobe epilepsy who experience cognitive challenges.
Not a fit: Patients without temporal lobe epilepsy or those whose cognitive issues are unrelated to seizure activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for cognitive deficits in patients with temporal lobe epilepsy.
How similar studies have performed: Previous research has indicated that understanding brain connectivity can provide insights into cognitive impairments, suggesting potential for success in this novel approach.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Englot, Dario J — Vanderbilt University Medical Center
- Study coordinator: Englot, Dario J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.