Understanding how brain connections relate to psychiatric disorders
Official title: Functional genomics of the human connectome in psychiatric illness
Funded at Rutgers Biomedical and Health Sciences · NIH-11049339 · Data updated 2026-11-12
This study is looking at how our genes and brain connections might affect mental health conditions like bipolar disorder, and it will follow patients over time to see how their brain activity and behaviors change.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | February 3, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $804,213 |
| NIH project number | 2R01MH120080-07A1 |
| Project ID | NIH-11049339 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with bipolar disorder or other related psychiatric conditions.
✕Less likely to help
Patients with psychiatric disorders not related to the functional connectome or those without a diagnosis may not benefit from this research.
What this research studies
This research investigates the biological origins of psychiatric illnesses by examining the functional connections in the brain, known as the functional connectome. It aims to understand how genetic factors and variations in brain network functioning contribute to different psychiatric symptoms over time. By analyzing large population studies, the research seeks to identify patterns that may explain the comorbidity of various disorders, such as bipolar disorder. Patients may be monitored over time to assess changes in their brain connectivity and behavior.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted treatments for psychiatric disorders.
How similar studies have gone: Previous research has shown promising results in understanding brain connectivity and its relation to psychiatric conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Holmes, Avram J — Rutgers Biomedical and Health Sciences
- Study coordinator: Holmes, Avram J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.