Understanding how brain connections help us remember similar experiences
A dynamic synaptic sensor controlling hippocampal CA3 circuit function
['FUNDING_R21'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10947158
This study is looking at how certain connections in the brain help us remember different experiences, and it’s designed for people interested in understanding memory better, especially how changes in a specific brain sensor might affect how we process memories.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10947158 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamic changes in synaptic strength within the hippocampus, a brain region crucial for forming episodic memories. By examining the mossy fiber synapses between specific neurons, the study aims to understand how these connections help distinguish between similar memories. The researchers will create a special animal model to observe how altering a key calcium sensor affects memory processing. This approach could reveal important insights into cognitive functions and memory encoding.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive deficits, particularly those related to memory.
Not a fit: Patients with no cognitive impairments or those not experiencing memory-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving memory function in individuals with cognitive deficits.
How similar studies have performed: Other research has shown promising results in understanding synaptic functions in memory, making this approach a valuable continuation of existing knowledge.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONTRACTOR, ANIS — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: CONTRACTOR, ANIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.