Understanding how brain connections develop in youth and relate to psychosis risk
Development of Cerebellar-Cortical Functional Connectivity in Youth and Its Prediction of Psychosis
This study is looking at how the brain develops in young people and whether certain changes can help us understand who might be at risk for experiencing psychosis later on, using brain scans and tests from over 3,000 kids and young adults aged 5 to 21.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project ID | NIH-11029636 on NIH RePORTER |
What this research studies
This research investigates the development of connections between the cerebellum and cortex in young individuals and how these connections may predict the onset of psychosis. By analyzing data from large neurodevelopmental datasets, including brain scans and clinical assessments of over 3000 participants aged 5 to 21, the study aims to identify normal developmental patterns and deviations that could indicate a higher risk for psychotic symptoms. The approach combines advanced imaging techniques with comprehensive cognitive evaluations to provide insights into the neurodevelopmental processes associated with psychosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 5 to 21 who may be at clinical high risk for psychosis or exhibit cognitive disturbances.
Not a fit: Patients outside the age range of 5 to 21 or those without any risk factors for psychosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early identification and intervention strategies for youth at risk of developing psychosis.
How similar studies have performed: Previous research has shown promising results in understanding brain connectivity and its implications for mental health, suggesting that this approach could yield valuable insights.
Where this research is happening
Manhasset, United States
- Feinstein Institute for Medical Research — Manhasset, United States (Active)
Researchers
- Principal investigator: Cao, Hengyi — Feinstein Institute for Medical Research
- Study coordinator: Cao, Hengyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.