Understanding how brain connections develop in autism
Official title: Molecular and cellular mechanisms of inhibitory synapse development
Funded at University of California Riverside · NIH-11032034 · Data updated 2026-11-12
This study is looking at how certain brain cells might be causing overactive brain activity in autism, and it aims to find new ways to help improve brain function and behavior for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $434,085 |
| NIH project number | 5R01NS129555-02 |
| Project ID | NIH-11032034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are diagnosed with autism spectrum disorder.
✕Less likely to help
Patients with other neurodevelopmental disorders that do not involve inhibitory neuron dysfunction may not benefit from this research.
What this research studies
This research investigates the mechanisms that lead to hyperactive neuronal networks in the brain, particularly focusing on the role of inhibitory neurons and astrocytes in conditions like autism. By exploring how certain signaling pathways affect the development of these networks, the study aims to uncover new insights into the neural dysfunctions associated with autism. The researchers will utilize animal models to observe the effects of specific genetic variations and signaling interactions on brain function and behavior. This could help identify potential therapeutic targets for improving outcomes in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain function and social behaviors in children with autism.
How similar studies have gone: Previous research has shown promising results in understanding the role of inhibitory neurons in autism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Ethell, Iryna M — University of California Riverside
- Study coordinator: Ethell, Iryna M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.