Understanding how brain connections change over time
Official title: The mechanisms and functions of short-term synaptic plasticity
Funded at Oregon Health & Science University · NIH-11005381 · Data updated 2026-11-12
This study is looking at how certain molecules in the brain help our connections adapt quickly, which is important for learning and memory, and it could help us understand conditions like Alzheimer's and autism better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | January 15, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $396,519 |
| NIH project number | 5R01NS135048-02 |
| Project ID | NIH-11005381 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Alzheimer's disease or autism spectrum disorders.
✕Less likely to help
Patients with conditions unrelated to synaptic plasticity or cognitive function may not benefit from this research.
What this research studies
This research investigates the mechanisms behind short-term synaptic plasticity, which is the brain's ability to adapt its connections rapidly. By studying specific molecules called Synaptotagmins, the research aims to uncover how these molecules influence neuronal signaling and contribute to learning and memory. The approach involves in vivo manipulations to observe these processes in real-time, providing insights into how the brain processes information. This could lead to a better understanding of various neurological conditions, including Alzheimer's disease and autism spectrum disorders.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function and lead to new treatments for cognitive disorders.
How similar studies have gone: Previous research has shown promising results in understanding synaptic plasticity, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Jackman, Skyler Lofstrand — Oregon Health & Science University
- Study coordinator: Jackman, Skyler Lofstrand
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.