Understanding how brain connections change over time
The mechanisms and functions of short-term synaptic plasticity
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11005381
This study is looking at how certain molecules in the brain help our connections adapt quickly, which is important for learning and memory, and it could help us understand conditions like Alzheimer's and autism better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11005381 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind short-term synaptic plasticity, which is the brain's ability to adapt its connections rapidly. By studying specific molecules called Synaptotagmins, the research aims to uncover how these molecules influence neuronal signaling and contribute to learning and memory. The approach involves in vivo manipulations to observe these processes in real-time, providing insights into how the brain processes information. This could lead to a better understanding of various neurological conditions, including Alzheimer's disease and autism spectrum disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Alzheimer's disease or autism spectrum disorders.
Not a fit: Patients with conditions unrelated to synaptic plasticity or cognitive function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function and lead to new treatments for cognitive disorders.
How similar studies have performed: Previous research has shown promising results in understanding synaptic plasticity, suggesting that this approach could yield valuable insights.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACKMAN, SKYLER LOFSTRAND — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: JACKMAN, SKYLER LOFSTRAND
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease