Understanding how brain connections change during learning and memory.
Multiscale theory of synapse function with model reduction by machine learning
This study is looking at how brain cells connect and change when we learn and remember things, using smart computer tools to help understand these processes better, which could eventually lead to new treatments for conditions like Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10263653 on NIH RePORTER |
What this research studies
This research investigates the processes that govern how connections between brain cells, known as synapses, change during learning and memory. By utilizing advanced machine learning techniques, the project aims to create a comprehensive model that links molecular signaling pathways to the structural changes in synapses. This approach allows researchers to study the interactions between calcium signaling and actin cytoskeleton growth, which are crucial for synaptic function. The findings could lead to better understanding of conditions like Alzheimer's disease and inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing early symptoms of Alzheimer's disease or those at risk for developing it.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of memory and learning, potentially offering new therapeutic targets for Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using machine learning for modeling biological processes, indicating potential success for this novel approach.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Mjolsness, Eric D — University of California-Irvine
- Study coordinator: Mjolsness, Eric D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.