Understanding how brain connections affect learning and memory as we age
Official title: Molecular and functional implications of thalamo-striatal synapse regulation in learning and memory
Funded at University of Minnesota · NIH-10996284 · Data updated 2026-11-12
This study is looking at how changes in certain brain connections affect our ability to adapt to new situations as we age, and it aims to help us understand why these changes happen and how they might lead to difficulties in thinking, so that we can find ways to improve cognitive health for everyone.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $39,726 |
| NIH project number | 1F31MH136679-01A1 |
| Project ID | NIH-10996284 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over the age of 21 who are experiencing cognitive changes or declines associated with aging.
✕Less likely to help
Patients with cognitive impairments due to acute neurological conditions or injuries may not benefit from this research.
What this research studies
This research investigates how changes in specific brain connections, particularly in the thalamo-striatal synapses, influence cognitive flexibility, which is crucial for adapting to new situations. The study aims to uncover the mechanisms behind the decline of these synapses during aging and how this decline affects cognitive abilities. By using advanced imaging techniques and molecular analysis, the research seeks to provide insights into the structural and functional changes in the brain that contribute to cognitive impairments. Patients may benefit from a better understanding of cognitive decline and potential interventions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving cognitive flexibility and overall brain health in aging individuals.
How similar studies have gone: Previous research has shown promising results in understanding cognitive decline through similar approaches, particularly focusing on brain connectivity and function.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Rozema, Nicholas — University of Minnesota
- Study coordinator: Rozema, Nicholas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.