Understanding how brain circuits support memory and decision-making
Official title: Mechanisms of neural circuit dynamics in working memory and decision-making
Funded at Princeton University · NIH-10900680 · Data updated 2026-11-12
This study is looking at how different parts of the brain work together to help us remember things and make decisions, using fun virtual reality tasks with mice, to learn more about how our brains function and potentially improve treatments for memory-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | August 8, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $4,221,697 |
| NIH project number | 5U19NS132720-02 |
| Project ID | NIH-10900680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with cognitive impairments related to conditions such as Alzheimer's disease, ADHD, or autism spectrum disorders.
✕Less likely to help
Patients with purely physical health conditions unrelated to cognitive function may not receive any benefit from this research.
What this research studies
This research investigates the neural mechanisms that underlie working memory and decision-making by studying how different brain regions communicate and process information. Using advanced experimental techniques, including virtual reality tasks with mice, the researchers aim to uncover how neurons activate in sequences to support cognitive functions. The project combines experimental data with computational modeling to analyze brain activity patterns and their relationship to memory tasks. By identifying the specific neural circuits involved, the research seeks to provide insights into fundamental brain functions that could inform treatments for cognitive disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive disorders like Alzheimer's disease and ADHD.
How similar studies have gone: Previous research has shown promising results in understanding neural circuits related to cognitive processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Brody, Carlos D — Princeton University
- Study coordinator: Brody, Carlos D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.