Understanding how brain circuits respond to social stress
Prefrontal-Accumbens Neurocircuits Mediating Response to Social Stress
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-11056148
This study is looking at how stress affects social behavior by using mice to understand the brain areas involved, with the hope of finding new ways to help people who struggle with social interactions due to stress.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11056148 on ClinicalTrials.gov |
What this research studies
This research investigates the brain mechanisms that lead to impaired social behavior due to stress, using a mouse model of chronic social defeat stress. By examining specific neural circuits in the medial prefrontal cortex, the study aims to identify how these circuits contribute to social deficits. The researchers will utilize advanced techniques to observe neuronal activity and explore potential therapeutic strategies to target these circuits for improved social functioning.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing social behavior impairments related to chronic stress or depression.
Not a fit: Patients with acute stress responses or those not exhibiting social behavior impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for social impairments associated with stress-related neuropsychiatric conditions.
How similar studies have performed: Previous research has shown promise in understanding brain circuits related to stress, but this specific approach is novel and aims to develop targeted interventions.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FERGUSON, DEVEROUX — UNIVERSITY OF ARIZONA
- Study coordinator: FERGUSON, DEVEROUX
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.