Understanding how brain circuits process pain signals
Official title: Synaptic mechanisms of somatosensory circuit assembly
Funded at Washington University · NIH-11000814 · Data updated 2026-11-12
This study is looking at how certain brain molecules help create the connections that process pain signals, with the hope of finding new ways to understand and treat chronic pain for people who suffer from it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $461,529 |
| NIH project number | 5R01NS130046-03 |
| Project ID | NIH-11000814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic pain conditions, particularly those who have not responded well to current treatments.
✕Less likely to help
Patients with acute pain or those not experiencing chronic pain conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms by which specific molecules in the brain help form connections that process sensory information related to pain. By examining how these molecules influence the assembly and function of pain-related circuits in the spinal cord, the researchers aim to uncover new insights into chronic pain conditions. The study employs advanced techniques such as gene knockout, viral tracing, and optogenetics to explore these complex interactions. Patients may benefit from a better understanding of pain mechanisms, potentially leading to improved treatments.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective pain management strategies with reduced risk of addiction.
How similar studies have gone: Other research has shown promise in understanding pain mechanisms through similar approaches, indicating potential for significant advancements in treatment.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Copits, Bryan — Washington University
- Study coordinator: Copits, Bryan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.