Understanding how brain circuits influence social behavior using advanced technology
Neural Circuit Mechanisms Mediating TMS and Oxytocin Effects on Social Cognition
This study is looking at how certain brain activities influence social behavior in monkeys, using techniques like brain stimulation and hormone treatments, to help us better understand social interactions and potentially improve our knowledge of conditions like autism.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11041144 on NIH RePORTER |
What this research studies
This research investigates the neural mechanisms that affect social cognition by examining how brain circuits in primates, particularly macaques, respond to interventions like transcranial magnetic stimulation (TMS) and oxytocin. The study employs innovative techniques such as wireless neurophysiological recordings and computer vision to analyze social interactions in natural settings. By manipulating neural activity and observing behavioral changes, the research aims to uncover the biological underpinnings of social behavior, which could have implications for understanding conditions like autism spectrum disorder.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with autism spectrum disorder or related social cognition difficulties.
Not a fit: Patients who do not have social cognition challenges or related conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving social cognition in individuals with social behavior challenges.
How similar studies have performed: While this approach is innovative and has not been previously attempted in macaques, similar studies in other contexts have shown promise in understanding social behavior.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Platt, Michael L — University of Pennsylvania
- Study coordinator: Platt, Michael L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.