Understanding how brain circuits influence opioid seeking behavior
Thalamostriatal Circuitry in Opioid Seeking
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-11011487
This study is looking at how the brain changes in people with opioid use disorder when they seek out opioids, using mice to help understand what happens in the brain during drug use and relapse, which could lead to better ways to help people struggling with addiction.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-11011487 on ClinicalTrials.gov |
What this research studies
This research investigates the brain systems that contribute to opioid seeking behaviors in individuals with opioid use disorder (OUD). Using advanced techniques like two-photon calcium imaging, the study tracks neuron activity in mice during different phases of heroin use, including self-administration and relapse. By examining how certain brain circuits are altered by opioid use, the research aims to uncover the mechanisms that trigger unproductive reward-seeking behaviors in response to cues. This could lead to better understanding and potential interventions for opioid addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with opioid use disorder who may benefit from improved treatment options.
Not a fit: Patients who do not have opioid use disorder or are not affected by opioid addiction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing relapse in individuals with opioid use disorder.
How similar studies have performed: While the specific approach of tracking neuron activity in this manner is novel, similar research has shown promise in understanding addiction mechanisms.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OTIS, JAMES M — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: OTIS, JAMES M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder