Understanding how brain circuits influence decision-making in addiction and compulsive behaviors
The role of cortico-striatal circuitry in model-based decision-making
This study is looking at how certain brain areas help mice make smart choices when things change, which could help us understand decision-making in people with conditions like addiction and eating disorders.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11052157 on NIH RePORTER |
What this research studies
This research investigates how specific brain circuits, particularly in the prelimbic cortex and dorsomedial striatum, contribute to decision-making processes that adapt to changing situations. By using advanced techniques like in vivo electrophysiology and optogenetics, the study aims to observe and manipulate neural activity in mice during decision-making tasks. The focus is on understanding model-based control, a cognitive system that helps individuals make informed choices, especially in the context of compulsive disorders such as addiction and eating disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing addiction or compulsive behaviors, as well as those with related psychiatric symptoms.
Not a fit: Patients who do not have issues related to addiction or compulsive behaviors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for individuals suffering from addiction and other compulsive disorders.
How similar studies have performed: Previous research has shown promising results in understanding brain circuitry related to decision-making, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Geramita, Matthew a. — University of Pittsburgh at Pittsburgh
- Study coordinator: Geramita, Matthew a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.