Understanding how brain circuits influence decision-making and addiction

CRCNS: Decision dynamics in cortico-basal ganglia-thalamic networks

NIH-funded research Carnegie-Mellon University · NIH-11087511

This study looks at how certain brain networks help us make decisions, especially when it comes to issues like opioid addiction and obesity, to find ways to improve treatments for these conditions.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionCarnegie-Mellon University NIH-funded
Lab location1 site (Pittsburgh, United States)
Project IDNIH-11087511 on NIH RePORTER

What this research studies

This research investigates how specific brain circuits, known as cortico-basal-ganglia-thalamic (CBGT) networks, process information to help make decisions, especially in the context of addictive behaviors like opioid addiction and obesity. By combining theoretical models and empirical investigations, the research aims to uncover how these circuits adapt to changing environments and feedback, which is crucial for understanding decision-making processes. Patients may benefit from insights gained about how these brain pathways function and how they can be targeted for treatment of addiction-related disorders.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals struggling with addiction or obesity, as well as those interested in understanding the neurological basis of their decision-making behaviors.

Not a fit: Patients who do not have issues related to addiction or obesity may not receive direct benefits from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatments for addiction and related disorders by enhancing our understanding of decision-making processes in the brain.

How similar studies have performed: Previous research has shown promise in understanding brain circuits related to decision-making and addiction, suggesting that this approach could yield valuable insights.

Where this research is happening

Pittsburgh, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions addictive disorder
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.