Understanding how brain circuits influence behavior and decision-making
Topological bridges between circuits, models, and behavior
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10795722
This study looks at how brain cells work together to influence our decisions and behaviors, especially how certain types of brain cells can affect our thinking and perception, which could help us understand cognitive disorders better and lead to new treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10795722 on ClinicalTrials.gov |
What this research studies
This research investigates the complex relationship between neuronal activity and behavior, focusing on how nonlinear interactions among neurons affect decision-making processes. By employing advanced mathematical techniques from algebraic topology, the study aims to analyze the dynamic activity of neuronal populations in a more holistic manner. The project will explore how different types of inhibitory interneurons influence cognitive functions and perceptual decisions, providing insights into the underlying mechanisms of brain function. Patients may benefit from a better understanding of cognitive disorders and potential new therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cognitive impairments or disorders affecting decision-making.
Not a fit: Patients with purely physical health issues unrelated to cognitive function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive disorders by enhancing our understanding of brain function and decision-making processes.
How similar studies have performed: Other research has shown promise in using nonlinear analysis methods to understand brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUNYAN, CAROLINE ANNE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: RUNYAN, CAROLINE ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.