Understanding how brain circuits in the subiculum contribute to epilepsy
Microcircuits of the Subiculum and Epilepsy
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11054655
This study is looking at how a part of the brain called the subiculum might play a role in causing seizures for people with temporal lobe epilepsy, and it hopes to find new ways to help treat this condition by understanding how brain cells work together.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11054655 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the subiculum, a part of the brain involved in various functions, in the development of temporal lobe epilepsy (TLE). It focuses on how specific brain cells and their interactions can lead to seizures when certain inhibitory mechanisms are disrupted. By studying these circuits in detail, the research aims to uncover the underlying biological processes that contribute to epilepsy, potentially leading to new treatment strategies. The approach includes advanced techniques to analyze brain tissue and cell interactions in both normal and pathological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with temporal lobe epilepsy or those experiencing recurrent seizures.
Not a fit: Patients with epilepsy types other than temporal lobe epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with temporal lobe epilepsy, potentially reducing the frequency and severity of seizures.
How similar studies have performed: Previous research has shown promising results in understanding the role of brain circuits in epilepsy, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACCAFERRI, GIANMARIA — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: MACCAFERRI, GIANMARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.